Acceleration of Gastrointestinal Tract Content Transfer and Inhibition of .ALPHA.-Glucosidases by an Edible Chrysanthemum Flower "Kakinomoto", a Traditional Vegetable of Niigata

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  • Kobayashi Yoshinori
    Laboratory of Pharmacognosy, School of Pharmaceutical Sciences, Kitasato University
  • Hasegawa Ryohei
    Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Sciences
  • Isogawa Misaki
    Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Sciences

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  • 新潟の食用菊“かきのもと”の胃腸管運動の亢進および二糖類分解酵素阻害作用
  • ニイガタ ノ ショクヨウ キク カキ ノ モト ノ イチョウカン ウンドウ ノ コウシン オヨビ ニ トウルイ ブンカイ コウソ ソガイ サヨウ

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Abstract

The traditional vegetable “Kakinomoto”, found in Niigata, is a type of edible chrysanthemum flower, Chrysanthemum morifolium Ramat. forma esculentum Makino. This study examined the effect of this edible chrysanthemum on gastrointestinal transit, digestion and absorption. A hot water extract of the edible chrysanthemum flower petals was added to a mixture of olive oil and sucrose solution at 10% by weight, and administered orally to mice. The edible chrysanthemum extract showed remarkable enhancement of gastrointestinal transit, reduction of the blood triglyceride level, and inhibition of blood glucose level elevation. The edible chrysanthemum extract also showed strong inhibitory activity against α-glucosidase derived from rat small intestine. The 50% inhibitory concentrations for sucrase and maltase were 34.6 and 20.0 mg/mL, respectively. In the 50-g sucrose tolerance test in 11 human volunteers, lyophilized powder of the edible chrysanthemum added to sucrose solution at 10% by weight significantly decreased the rise in the blood glucose level at 15 min and 30 min after sucrose loading, and reduced the integrated value of the area under the curve (ΔAUC) of the blood glucose level for 60 min after sucrose loading. These results suggest that the edible chrysanthemum “Kakinomoto” has promise as a functional food material with a suppressive effect on postprandial blood glucose level elevation.

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