Protective Effects of a Water-soluble Extract from Culture Medium of Ganoderma lucidum Mycelia against Neuronal Damage after Cerebral Ischemia/Reperfusion in Diabetic Rats

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  • Iwata Naohiro
    Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University
  • Okazaki Mari
    Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University
  • Kasahara Chisato
    Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University
  • Kamiuchi Shinya
    Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University
  • Suzuki Fumiko
    Noda Shokukinkogyo Co. Ltd.
  • Iizuka Hirosh
    Noda Shokukinkogyo Co. Ltd.
  • Hibino Yasuhide
    Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University

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Other Title
  • 糖尿病態ラットの一過性脳虚血誘発脳障害に対する霊芝菌糸体培養培地抽出物の保護効果
  • 糖尿病態ラットの一過性脳虚血誘発脳障害に対する霊芝菌糸培養培地抽出物の保護効果
  • トウニョウビョウタイ ラット ノ イッカセイ ノウキョケツ ユウハツ ノウショウガイ ニ タイスル レイシ キンシ バイヨウ バイチ チュウシュツブツ ノ ホゴ コウカ

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Abstract

Diabetes mellitus (DM) has been shown to enhance oxidative stress, leading to aggravation of cerebral ischemic injury following stroke. In this study, we examined the effects of daily administration of a water-soluble extract from culture medium of Ganoderma lucidum mycelia (WER) on total plasma oxidative stress, antioxidant capacity and activity of antioxidant enzymes (superoxide dismutase and catalase) in the brain of rats with streptozotocin (STZ)-induced diabetes. We also investigated whether WER ameliorates the exacerbation of neuronal damage induced by middle cerebral artery occlusion (MCAO) followed by reperfusion in a diabetic state. Male SD rats were treated with STZ (60 mg/kg, i.p.) and housed for 5 weeks for induction of an experimental diabetic state. WER (1 g/kg) was then administered orally for an additional 2 weeks. DM rats had increased oxidative stress and decreased plasma antioxidant capacity in comparison with non-DM rats. Furthermore, the activity of antioxidant enzymes was decreased in the DM rat brain. DM rats treated with WER showed normal levels of all these parameters. The diabetic state markedly aggravated MCAO/reperfusion-induced neurological deficits and cerebral injury assessed by infarct volume. Treatment with WER markedly improved both of these parameters in diabetic rats. These results show that daily intake of WER relieves the exacerbation of cerebral ischemic injury in a diabetic state, and that this may be attributable to amelioration of augmented oxidative stress.

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