Activation of Autonomic Nervous System Activity by the Oral Ingestion of GABA

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  • Fujibayashi Mami
    Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University
  • Kamiya Tomoyasu
    Research and Development Division, TOYO SHINYAKU Co., Ltd.
  • Takagaki Kinya
    Research and Development Division, TOYO SHINYAKU Co., Ltd.
  • Moritani Toshio
    Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University

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Other Title
  • ＧＡＢＡ経口摂取による自律神経活動の活性化
  • GABA ケイコウ セッシュ ニ ヨル ジリツ シンケイ カツドウ ノ カッセイカ

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The purpose of the present study was to investigate the acute effect of orally administered GABA on changes in autonomic nervous system (ANS) activity in young healthy males. Using a double-blind, random crossover design, 12 males (aged 21.7±0.8 yr) consumed a placebo or GABA-containing (30 mg per meal) capsules after an overnight fast. ANS activity was evaluated by means of heart rate variability power spectral analysis before and after administration for 30 and 60 min. There were significant increases in overall ANS and parasympathetic nervous system activities after GABA ingestion. The present results suggest that GABA may induce relaxation effects by modulating ANS activity.

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