Effect of corticosteroids in 10 cases of methimazole-induced agranulocytosis.

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Abstract

The effect of corticosteroids on the inception of remission was investigated in 10 patients with methimazole induced agranulocytosis. While remission started 6.00±0.92 days (mean±SE) after discontinuation of methimazole in 6 patients to whom corticosteroids were administered immediately after the cessation of methimazole treatment, it started at a significantly later date (9.25±0.48days after discontinuation of methimazole) in 4 patients in whom the corticosteroid treatment was started 5.5±0.5 days after methimazole ceased to be used. The results suggested that corticosteroids may quicken the recovery from methimazole-induced agranulocytosis.

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