Inhibition of Sucrose Digestion and Absorption by L-Arabinose in Rats.

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  • SANAI Kazuko
    Central Research Laboratory, Godo Shusei Co.
  • SERI Kenji
    Central Research Laboratory, Godo Shusei Co.
  • INOUE Shuji
    Division of Geriatric Health & Nutrition, National Institute of Health & Nutrition

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  • ラットにおけるショ糖の消化吸収およびエネルギー代謝に対するＬ‐アラビノースの抑制作用
  • ラット ニ オケル ショトウ ノ ショウカ キュウシュウ オヨビ エネルギー

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Abstract

L-arabinose, a natural, sweet and less absorptive pentose, has been recognized to have a selective inhibitory effect on intestinal sucrase activity. In this study, we evaluated the effects of L-arabinose on gastrointestinal digestion and absorption of 14C-labeled sucrose in rats, and also studied the suppressive effects of L-arabinose on the increase in blood glucose after sucrose loading. Uniformly 14C-labeled sucrose was orally administered at a dose of 2.5g/kg with or without L-arabinose, and cumulative expiratory 14CO2 and residual radioactivities in the gastrointestinal tract were measured for 6h. The cumulative expiratory 14CO2 was significantly reduced dose-dependently by L-arabinose (50, 250mg/kg), and also a large quantity of undigested 14C-labeled sucrose and its metabolites was observed in the cecum in L-arabinose-treated rats. We also observed potent suppressive effects of L-arabinose on the increase of blood glucose after sucrose loading in rats. These results indicate that L-arabinose delays and reduces the digestion, absorption and net energy of sucrose when both are simultaneously ingested.

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