Regulatory Effect of Nutritional Status on Albumin Synthesis  (Young Investigator Award of JSNFS (2010))

Kuwahata Masashi

doi:10.4327/jsnfs.64.215

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Other Title

栄養状態によるアルブミン合成の調節機構に関する研究　　（平成２２年度日本栄養・食糧学会奨励賞受賞）
エイヨウジョウタイニヨルアルブミンゴウセイノチョウセツキコウニカンスルケンキュウヘイセイ 22ネンドニホンエイヨウショクリョウガッカイショウレイショウジュショウ
Regulatory Effect of Nutritional Status on Albumin Synthesis
(Young Investigator Award of JSNFS (2010))
(平成22年度日本栄養・食糧学会奨励賞受賞)

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Description

Serum albumin has become an indispensable factor for evaluation of nutritional status. In the regulation of albumin synthesis, stimulation resulting from ingestion of a meal is one of the most important factors. Transcription of the albumin gene is known to be influenced by protein nutrition status, and we have shown that modulation of albumin gene expression by amino acid supply in rat liver is mediated through the intracellular concentration of pyridoxal 5′-phosphate. We suggest that pyridoxal 5′-phosphate interacts directly with a tissue-specific transcription factor and modulates binding to the albumin gene. Post-transcriptional regulation plays an important role in the reduction of albumin synthesis under fasting conditions. Polypyrimidine tract-binding protein (PTB) is an abundant eukaryotic RNA-binding protein. We have shown that binding of PTB to the coding region of albumin mRNA suppresses its translation. We suggest that alterations in the level of the albumin mRNA-PTB complex are involved in the regulation of albumin synthesis in fasted rats.

Journal

Nippon Eiyo Shokuryo Gakkaishi

Nippon Eiyo Shokuryo Gakkaishi 64 (4), 215-219, 2011

Japan Society of Nutrition and Food Science

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Regulatory Effect of Nutritional Status on Albumin Synthesis (Young Investigator Award of JSNFS (2010))