ラット血清および組織中のペンタクロロベンゼン蓄積抑制に及ぼす各種リン脂質投与の効果

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  • Suppression of Pentachlorobenzene Accumulation in Rat Serum and Tissues by Various Dietary Phospholipids.
  • ラット ケッセイ オヨビ ソシキ チュウ ノ ペンタクロロベンゼン チクセキ ヨクセイ ニ オヨボス カクシュ リン シシツ トウヨ ノ コウカ

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Effects of dietary phospholipids on the accumulation of pentachlorobenzene (PECB) in serum and tissues of rats were examined. Male Sprague-Dawley rats aged 4 weeks were fed for 2 weeks on a 5% lard AIN-76 diet containing 0.1% PECB. Each diet was supplemented with 5% olive oil (OliO), rapeseed (RapO), egg yolk phospholipids (EggPL), low lecithin soybean phospholipids (SoyPL-L), high lecithin soybean phospholipids (SoyPL-H), or rapeseed phospholipids (RapPL), respectively. Weight gain and food intake did not differ significantly among the 6 groups. Concentrations of serum cholesterols (CH) and phospholipids in the SoyPL-L group were significantly lower than those in the OliO group. Triglyceride (TG) concentrations in all the phospholipids groups were lower than that in the OliO group. The CH and TG concentrations in the liver showed a similar tendency to those in serum in all groups. The PECB concentrations in liver and serum were decreased in all the phospholipid groups, especially the SoyPL-L group, compared with the OliO and RapO groups. On the other hand, the PECB concentration in the kidney in the SoyPL-L group was rather higher than that in the OliO group. The PECB concentrations in the epididymal fat pad in the phospholipid groups expect for the RapPL group were lower than that in the OliO group. These results suggest that dietary phospholipids effectively decrease the concentration of serum lipids and the accumulation of PECB in tissues. Also it is assumed that these effects may depend on the phospholipid class and fatty acid patterns.

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