Effect of Docosahexaenoic Acid-enriched Chlorella vulgaris CK22 on Serum Lipids in Rats Fed a Cholesterol-Supplemented Diet.

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  • ドコサヘキサエン酸を富化したクロレラ・ブルガリス（Ｃｈｌｏｒｅｌｌａ　ｖｕｌｇａｒｉｓ）ＣＫ２２株の投与による高コレステロール摂餌ラット血清脂質上昇抑制作用
  • ドコサヘキサエンサン オ フカ シタ クロレラ ブルガリス Chlorella vulgaris CK22カブ ノ トウヨ ニ ヨル コウコレステロールセツジ ラット ケッセイ シシツ ジョウショウ ヨクセイ サヨウ

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The antihyperlipidemic effect of DHA-enriched Chlorella vulgaris CK22 (D-CVP) has been studied in a rat model. The hyperlipidemic diet used was based on the AIN93 formula, where the lipid is lard instead of soybean oil. Added to this diet was 1% cholesterol and 0.5% cholate, together with either 0%, 5%, 10% or 20% D-CVP, 20% CVP, or 0.9% DHA oil. After 4 weeks, serum T-CHO and TG levels were elevated in the group administered the hypercholesterolemic diet. The strongest anti-hyperlipidemic effect was shown in the D-CVP group, and the prevention of serum T-CHO elevation was due to the diet's lowering effect on LDL-C. HDL-C was not influenced by these diet treatments. D-CVP showed a very strong preventative effect on not only liver T-CHO and TG elevation but also visceral fat pad weight. However, D-CVP and CVP were equally effective in protecting against increases in liver weight and liver lipid content. The anti-hyperlipidemic effects of D-CVP may be represented by a supplementary correlation between its DHA and CVP components. D-CVP lowered the serum LPO level, and therefore appears to be a promising candidate for prevention of lifestyle-related diseases that afflict the elderly.

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