Influence of Protein Re-feeding on Hepcidin Kinetics and Iron Metabolism in Rats with Protein-energy Malnutrition
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- Sakata Fumiko
- Terumo Corporation R & D Headquarters
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- Sasaki Katsunori
- Department of Gastrointestinal Immunology and Regenerative Medicine, Asahikawa Medical University
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- Uchida Takayuki
- Terumo Corporation R & D Headquarters
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- Chiku Kazuo
- Terumo Corporation R & D Headquarters
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- Kohgo Yutaka
- Division of Gastroenterology and Hematology/Oncology Department of Medicine, Asahikawa Medical University
Bibliographic Information
- Other Title
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- タンパク質・エネルギー栄養障害ラットのタンパク質再摂取がヘプシジン動態と鉄代謝に及ぼす影響
- タンパクシツ ・ エネルギー エイヨウ ショウガイ ラット ノ タンパクシツ サイセッシュ ガ ヘプシジン ドウタイ ト テツ タイシャ ニ オヨボス エイキョウ
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Abstract
Previously, we have reported that rats with protein-energy malnutrition suffer from impaired iron metabolism due to induction of hepcidin-25. Supply of iron under conditions of high levels of hepcidin-25 would carry a risk of iron overload. In this study, hepcidin-25 kinetics and iron metabolism were investigated after protein re-feeding in rats with protein-energy malnutrition. Iron metabolism under conditions of iron supply was also investigated. Supply of protein in the protein re-feeding period allowed an increase of hepcidin-25 in serum, followed by a temporary reduction, and enhancement of iron deposition in the spleen. On the other hand, when no iron was supplied, iron deficiency anemia occurred, but slight iron deposition in the spleen was still observed. These results suggest that in protein-energy malnutrition, impairment of iron utilization may persist even after protein re-feeding once the protein has accumulated.
Journal
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- Nippon Eiyo Shokuryo Gakkaishi
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Nippon Eiyo Shokuryo Gakkaishi 68 (1), 19-23, 2015
Japan Society of Nutrition and Food Science
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Details 詳細情報について
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- CRID
- 1390001206293821312
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- NII Article ID
- 130004769773
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- NII Book ID
- AN00311992
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- ISSN
- 18832849
- 02873516
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- NDL BIB ID
- 026157962
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- Text Lang
- ja
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed