-
- 林 伸一
- 東京慈恵会医科大学生化学講座第二 (旧栄養学講座)
書誌事項
- タイトル別名
-
- A Track Record of Studies on the Regulatory Mechanism of Ornithine Decarboxylase. From Circadian Rhythms to Regulated Degradation.
- オルニチン ダツ タンサン コウソ ノ チョウセツ キジョ ケンキュウ ノ イ
- From Circadian Rhythms to Regulated Degradation
- 日周リズムから分解制御へ
この論文をさがす
説明
This paper summarizes the results of my quarter-century study on the regulatory mechanism of ornithine decarboxylase (ODC), a key enzyme in polyamine synthesis. ODC turns over rapidly and is under negative feedback regulation by polyamines, which accelerate ODC degradation and induce an ODC-inhibitory protein, antizyme. Rat-liver ODC levels exhibit a circadian rhythm with the peak at night, owing to the feeding pattern. The dietary induction of hepatic ODC depends on both the quantity and quality of dietary proteins. In order to clarify the molecular mechanism of ODC regulation, rat-liver ODC was purified to homogeneity. Antizyme was also highly purified and its cDNAs were obtained. Forced expression of antizyme caused rapid ODC degradation, proving that antizyme mediates polyamine-induced destabilization of ODC. In newly established in vitro ODC degradation systems, ODC is degraded in an ATP- and antizymedependent manner by 26 S proteasome without ubiquitination. Antizyme also inactivates polyamine uptake. Nucleotide sequence analysis of antizyme mRNA revealed that programmed ribosomal frameshifting evoked by polyamines is necessary for its translation.
収録刊行物
-
- 日本栄養・食糧学会誌
-
日本栄養・食糧学会誌 49 (1), 1-11, 1996
公益社団法人 日本栄養・食糧学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001206293870080
-
- NII論文ID
- 10009281997
-
- NII書誌ID
- AN00311992
-
- ISSN
- 18832849
- 02873516
-
- NDL書誌ID
- 3938052
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可
