Effect of Various Fractions Extracted from Mulberry Leaves on Lipid Metabolism in Rabbits Fed a Cholesterol Diet.

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  • コレステロール食摂餌ウサギにおける桑葉抽出画分の脂質代謝に及ぼす影響
  • コレステロールショクセツジ ウサギ ニ オケル ソウヨウ チュウシュツ カクブン ノ シシツ タイシャ ニ オヨボス エイキョウ

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Previously, we have demonstrated that intake of mulberry leaves suppresses increases in the concentrations of serum lipids, hepatic enlargement and atheromatous thickening of the arterial intima in hypercholesterolemic rabbits. In the present study, we evaluated the effect of extracts of mulberry leaves in hypercholesterolemic rabbits in order to clarify the active fractions. The rabbits were fed a 1% cholesterol diet (Ch) concomitantly containing 5% (5Bt·Ch) or 2.5% 1-butanol extract (2.5Bt·Ch), 5% acetone extract (Ac·Ch) and 5% residue (Re·Ch) of mulberry leaves for 14 weeks, respectively. Increases in the concentration of serum total cholesterol and free cholesterol were significantly suppressed in the 5Bt·Ch and Re·Ch diet groups compared with those in the Ch group. Furthermore, a tendency for suppression of lipid deposition in hepatocytes was observed in both the 5Bt·Ch and Re·Ch diet groups. These findings suggest that the hypolipidemic effects of mulberry leaves are exerted by multiple components, and that the 1-butanol extract (recovery 1.03%) contains more active components than the residue (recovery 83.31%).

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