Suppressive Effect of Dexamethasone on Morphine-Induced Adrenocorticoidogenesis in Rat
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- KUWAMURA TSUKASA
- Department of Pharmacology, The Jikei University School of Medicine
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- NAGAO SHIGEYUKI
- Department of Pharmacology, National Institute of Hygienic Sciences
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- NAKAURA SHINSUKE
- Department of Pharmacology, National Institute of Hygienic Sciences
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- KAWASHIMA KUNIO
- Department of Pharmacology, National Institute of Hygienic Sciences
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- TANAKA SATORU
- Department of Pharmacology, National Institute of Hygienic Sciences
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- OMORI YOSHIHITO
- Department of Pharmacology, The Jikei University School of Medicine
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- NAKAO TAKESHI
- Department of Pharmacology, The Jikei University School of Medicine
Bibliographic Information
- Other Title
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- Suppressive effect of dexamethasone on morphihe-induced adrenocorti-coidogenesis in rat
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Description
The effect of morphine on adrenal-pituitary axis function was examined by determination of adrenal and serum corticosterone changes in rats pretreated with dexamethasoe.<BR>Increases in both adrenal and serum corticosterone concentrations induced by a single dose of 20mg/Kg of morphine were almost completely inhibited by subcutaneous injection with 1mg/rat of dexamethasone 3 hr prior to morphine administration. However, no suppressive effect of dexamethasone was observed when a dose of 30μg/rat of synthetic ACTH was given.<BR>In morphinized rats, adrenal and serum corticosterone concentrations were not so significantly increased as observed in a single dose of morphine administration. However, corticosterone concentrations after the morphinization were increased strikingly by synthetic ACTH or nalorphine administration immediately after the final treatment of morphine. But these increases after nalorphine administration were inhibited entirely by the pretreatment with dexamethasone.<BR>On the bases of these findings, it was suggested that morphine dose not act directly corticoidogenesis in adrenal cortex but affects through the central nervous system.
Journal
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- Endocrinologia Japonica
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Endocrinologia Japonica 20 (4), 359-363, 1973
The Japan Endocrine Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001206297507328
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- NII Article ID
- 130000956673
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- NII Book ID
- AA00635052
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- ISSN
- 21856370
- 00137219
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- NDL BIB ID
- 7672893
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- PubMed
- 4357084
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed