Effect of synthetic corticotropins on human growth hormone secretion(Note)

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  • TAKAHARA JIRO
    Third Department of Internal Medicine, Okayama University Medical School
  • ASAOKA KATSUSHI
    Third Department of Internal Medicine, Okayama University Medical School
  • OFUJI TADASHI
    Third Department of Internal Medicine, Okayama University Medical School

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  • Effect of Synthetic Corticotropins on Human Growth Hormone Secretion

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Human growth hormone (HGH) secretion occurred following the administration of Gly1-ACTH (1-18) octadecapeptide amide (50022-S) which was synthetized by Otsuka.<BR>The mean response curve of plasma HGH after the intravenous administration of 0.35mg of 50022-S in 23 healthy subjects was similar to that of plasma cortisol.<BR>A significant increase in plasma HGH to 0.35mg of 50022-S was observed, while there was no significant increase in plasma HGH to 0.25 mg of 1-24 ACTH, which is a corresponding dose to 0.35mg of 50022-S in cortisol response.<BR>In most of the patients who had dysfunction of hypothalamic-pituitary axis, no significant increase in plasma HGH to 0.35mg of 50022-S was observed.<BR>From these results, we conclude that Gly1-ACTH (1-18) octadecapeptide amide (50022-S) has a potency to release growth hormone from the pituitary in man.

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