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- TANAKA AKIRA
- Shionogi Research Laboratory
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- FURUKAWA TAKAYOSHI
- Shionogi Research Laboratory
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Description
Effects of native ACTH and various synthetic ACTH analogues on water balance alcohol-anesthesized polyuria rats were examined. Purified porcine ACTH had an apparent anti-diuretic action on the rats. Synthetic ACTH peptides consisting of 27, 24, 17, and 16 amino acids were biphasic, initially diuretic then anti-diuretic, and the peptides having 14, 13, and 10 amino acids were only diuretic. Small ACTH fragments consisting of 8, 6, 5, and 4 amino acids were inactive in the doses so far examined. In analogues consisting of 18 amino acids, replacement of N-terminal amino acid with β-alanine orα-aminoisobutyric acid (Ibu) and protection of the C-terminal carboxyl group by amide formation enhanced the anti-diuretic action. Purified TSH, LH, FSH, and prolactin probably inert under the experimental condition. Similar biphasic effect of the Ibu1-ACTH (1-18)-amide was also observed in hypophysectomized or adrenalectomized rats with almost the same potency as that in nonoperated rats. Weak diuretic action of Ibu1-ACTH (1-18)-amide was also demonstrated in water-loaded intact rats.
Journal
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- Endocrinologia Japonica
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Endocrinologia Japonica 20 (1), 39-49, 1973
The Japan Endocrine Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001206297656192
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- NII Article ID
- 130000956635
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- NII Book ID
- AA00635052
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- ISSN
- 21856370
- 00137219
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- NDL BIB ID
- 7672855
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- PubMed
- 4353251
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed