Insulin releasing activity of gastrointestinal glucagon-like immunoreactive materials in perfused rat pancreas.

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  • TANAKA RYOICHI
    Department of Medicine and Geriatrics, Osaka University Medical School
  • MATSUYAMA TATSUO
    Second Department of Internal Medicine, Osaka University Medical School
  • SHIMA KENJI
    Department of Medicine and Geriatrics, Osaka University Medical School
  • SAWAZAKI NORIO
    Central Laboratory for Clinical Investigation, Osaka University Medical School
  • TARUI SEIICHIRO
    Second Department of Internal Medicine, Osaka University Medical School
  • KUMAHARA YUICHI
    Department of Medicine and Geriatrics, Osaka University Medical School

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タイトル別名
  • Insulin Releasing Activity of Gastroint

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Insulin-releasing activity of porcine gastrointestinal glucagon-like immunoreactive materials purified by affinity chromatography was examined in the perfused rat pancreas. When glucose concentration of the perfusate was raised from 60 to 100mg/dl, augmented insulin release was observed. The mean incremental area of immunoreactive insulin (ΣΔIRI) during the first 10min thus observed was 19.07±3.76ng/10min. Pancreatic glucagon and the extract from the gastric fundus showed the enhancement of insulin release in this system when they were added to the perfusate at the rate of 100ng/min for 5min;ΣΔIRI were 41.92±.47 and 71.70±18.09ng/10min, respectively, which were significantly higher than that of 100mg/dl of glucose alone. However, no significant diffrence in the insulinogenic activity was noticed between the extracts from the small intestine and the control.<BR>These results suggest that the extract from the gastric fundus has insulinogenic activity similar to that of pancreatic glucagon.

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