Investigation of the prognosis of patients with papillary thyroid carcinoma by tumor size
-
- Ito Yasuhiro
- Department of Surgery, Kuma Hospital, Kobe 650-0011, Japan
-
- Kihara Minoru
- Department of Surgery, Kuma Hospital, Kobe 650-0011, Japan
-
- Takamura Yuuki
- Department of Surgery, Kuma Hospital, Kobe 650-0011, Japan
-
- Kobayashi Kaoru
- Department of Surgery, Kuma Hospital, Kobe 650-0011, Japan
-
- Miya Akihiro
- Department of Surgery, Kuma Hospital, Kobe 650-0011, Japan
-
- Miyauchi Akira
- Department of Surgery, Kuma Hospital, Kobe 650-0011, Japan
この論文をさがす
説明
In papillary thyroid carcinoma (PTC), extrathyroid extension (Ex) and clinical lymph node metastasis (N) significantly affect the prognosis. We investigated the prognosis of patients with PTC 1 cm or less (1,220 patients), 1.1-2 cm (2,101 patients), 2.1-3 cm (1,249 patients), 3.1-4 cm (645 patients), and larger than 4 cm (563 patients). We classified N factor into three categories: N0, no clinical node metastasis: N1, clinical node metastasis smaller than 3 cm and without extranodal tumor extension requiring at least partial excision of adjacent organs for node dissection: and N2, clinical node metastasis 3 cm or larger or showing extranodal tumor extension. N2 markedly affected lymph node and distant recurrence-free survivals and cause-specific survival, regardless of the tumor size. N1 also adversely affected lymph node and distant recurrence-free survival but not cause-specific survival. Ex did not affect patients’ prognosis with PTC 1 cm or less. It became a prognostic factor with PTC larger than 1 cm, and worsened lymph node and distant recurrence-free survival not only for N0 but also for N1 PTC larger than 3 cm and larger than 2 cm, respectively. However, its influence is limited for N2 PTC patients. Furthermore, Ex worsened the CSS with PTC larger than 2 cm in combination with N2. We have to note that the prognostic significance for lymph node and distant recurrence-free and cause-specific survival of Ex and N varies according to the tumor size in order to accurately predict the clinical outcomes and establish therapeutic strategies for PTC patients.
収録刊行物
-
- Endocrine Journal
-
Endocrine Journal 59 (6), 457-464, 2012
一般社団法人 日本内分泌学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001206298508800
-
- NII論文ID
- 10030816654
-
- NII書誌ID
- AA10901436
-
- COI
- 1:STN:280:DC%2BC38vpsVeltg%3D%3D
-
- ISSN
- 13484540
- 09188959
-
- PubMed
- 22447137
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可