Effect of calcitonin on calcium concentration in serum and liver of rats ligated bile duct.

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  • YAMAGUCHI MASAYOSHI
    Department of Environmental Biochemistry, Shizuoka College of Pharmaceutical Science

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  • Effect of Calcitonin on Calcium Concent

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The effect of calcitonin (CT) on the serum and liver calcium is examined in rats ligated the bile duct. The subcutaneous administration of CT (80 MRC mU/100g BW) significantly prevented the increase of serum calcium concentration after a single oral injection of calcium (50mg/100g BW) to sham-operated rats. But the ligation of bile duct prevented the hypocalcemic effect of CT. Meanwhile, CT significantly increased the liver calcium content after the calcium injection to sham-operated rats. However, the liver calcium content after CT administration was markedly elevated by the ligation of bile duct in comparison with that of sham-operated rats. The present results suggest that the liver calcium increased by CT administration secretes into the bile.

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