Dexamethasone suppressibility of plasma pregnenolone (3.BETA.-hydroxy-5-pregnen-20-one) in normal men.

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  • NISHIDA SEIKOH
    Division of Endocrinology, Department of Medicine, Kawasaki Medical School
  • MATSUMURA SHIGEICHI
    Division of Endocrinology, Department of Medicine, Kawasaki Medical School
  • HORINO MASAHARU
    Division of Endocrinology, Department of Medicine, Kawasaki Medical School
  • OYAMA HIDEKI
    Division of Endocrinology, Department of Medicine, Kawasaki Medical School
  • TENKU ATSUKO
    Division of Endocrinology, Department of Medicine, Kawasaki Medical School

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  • Dexamethasone Suppressibility of Plasma Pregnenolone(3β-Hydroxy-5-pregnen-20-one)in Normal Men(Note)
  • Dexamethasone Suppressibility of Plasma

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In order to examine the dexamethasone suppressibility of plasma pregnenolone, 9 a.m. and overnight suppression tests were performed in normal adult subjects and plasma pregnenolone levels were radioimmunoassayed. The results were as follows: 1) In the 9 a.m. test, plasma pregnenolone was suppressed to the lowest level at the time between 30min and 2 hr after dexamethasone; 2) there was no significant difference in dexamethasone suppressibility of plasma pregnenolone between the 9 a.m. test and overnight test; 3) there was no significant difference from each other among the plasma pregnenolone levels after dexamethasone administration (0.5mg to 3mg) in both tests; 4) after dexamethasone administration, plasma pregnenolone was not suppressed below 40% of the basal level in both tests; 5) discussions were made about the results, comparing with those of the suppressibility of cortisol which were previously reported from this laboratory.

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