Activin A: Autocrine Regulator of Kidney Development and Repair

DOI Web Site 被引用文献9件 参考文献125件
  • MAESHIMA Akito
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
  • MIYA Masaaki
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
  • MISHIMA Keiichiro
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
  • YAMASHITA Shin
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
  • KOJIMA Itaru
    Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University
  • NOJIMA Yoshihisa
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine

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The research described in this review suggests a novel and important role for activin A in the developmental and repair processes of the kidney (Table 1). The results obtained in these studies indicate that activin A is a negative regulator of kidney development and plays an essential part in kidney diseases, such as acute renal failure or renal fibrosis. It is also possible that activin A is a key player in the pathophysiological processes of other kidney diseases, such as congenital urogenital abnormalities, renal cystic disease and renal cell carcinoma. Activin A is thus a potential target for therapeutic interventions in kidney diseases. To address this issue, more detailed analysis on the regulation of activin production, modulation of activin activity and activin target genes is required.<br>

収録刊行物

  • Endocrine Journal

    Endocrine Journal 55 (1), 1-9, 2008

    一般社団法人 日本内分泌学会

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