INFLUENCES OF VARIOUS CHEMICAL REAGENTS ON THE BIOLOGICAL ACTIVITIES OF S-PAROTIN

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  • AONUMA SHIGERU
    Pharmaceutical Faculty, University of Osaka
  • HAMA TAKAO
    Pharmaceutical Faculty, University of Osaka
  • HONDA HIROKO
    Pharmaceutical Faculty, University of Osaka
  • ITO YOSOJI
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, University of Tokyo
  • SHINODA MASATO
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, University of Tokyo

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  • STUDIES ON SUBMAXILLARY GLAND XII

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The activities of S-Parotin in aqueous solution were relatively stable against acid and alkaline. In solid state, S-Parotin could be stored for 4 years at room temperature without any remarkable loss of the activity. The activities reversiblly denaturated by urea. Ca-decreasing activity received non-reversible denaturation by guanidine hydrochloride, but Leucocytes decreasing and then increasing activity did not receive any denaturation. From the results of S-Parotin treated with nitrous acid, formaldehyde, iodine, cysteine and thioglycollic acid, it could concluded that there is no particularly responsible radical for the display of activities and the free amino radical and the tyrosine phenyl radical are responsible.

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