SEX REVERSAL IN FEMALE TADPOLES INDUCED BY THE TREATMENT WITH METHYLMERCAPTOIMIDAZOLE

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1. The tadpoles of Rhacophorus schlegelii were treated with methylmercaptoimidazole, and the effects of this substance on the thyroid gland and the gonad were studied.<BR>2. The metamorphosis-inhibiting effect of this substance is about ten times or more as strong as that of thiourea.<BR>3. The influence of this substance on the thyroid gland and the gonad is essentially the same as that of thiourea treatment.<BR>4. The acceleration of gonadal development and the sex reversal of female to male in higher anuran larvae induced by the treatment with thiourea are the common phenomena induced by any antithyroidal thiourea derivatives.<BR>5. It is interesting that the direction of sex differentiation of larval gonad is easily affected by the unusual changes of levels of hypophyseal hormones.

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