STUDIES ON ACID MUCOPOLYSACCHARIDES IN EXPERIMENTAL HYPER-AND HYPOPARATHYROIDISM

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  • SHIMADA OSAMU
    Department of 1st Surgery, Iwate Medical University Medical School

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Changes in acid mucopolysaccharide metabolism were studied using35S-sodium sulfate in experimental hyper-and hypoparathyroidism in rats. Urinary excretion of35S, reaching the maximum 12 hrs. after the administration of isotope, was higher in hyperparathyroidism and lower in hypoparathyroidism than in controls. In bone tissue, 35S activity showed a marked increase in the groups with parathyroid extract administration, especially in the incisor and epiphyses during the process of growth. The concentration of35S also increased in the kidney, liver, muscle and skin in hyperparathyroidism, while the slight changes or a tendency to decrease was seen in hypoparathyroidism.35S in serum albumin andγ-globulin fractions increased in hyperparathyroidism and showed a tendency to slight decrease in hypoparathyroidism.35S inα-globulin increased and35S in β-globulin showed a decrease in all experimental animals as compared with controls.

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