Effects of Glycyrrhizin and Cortisone on Cholesterol Metabolism in the Rat

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  • YAMAMOTO MASAHIRO
    The Third Department of Internal Medicine, School of Medicine, Osaka University
  • TAKEUCHI NOZOMU
    The Third Department of Internal Medicine, School of Medicine, Osaka University
  • KOTANI SATORU
    The Third Department of Internal Medicine, School of Medicine, Osaka University
  • KUMAGAI AKIRA
    The Third Department of Internal Medicine, School of Medicine, Osaka University

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Effects of glycyrrhizin, an active principle of liquorice, on cholesterol metabolism, and its correlation with cortisone action were investigated using adrenalectomized rats.(1) Incorporation of acetate-1-14C and mevalonate-5-3H into cholesterol of liver slices was greatly stimulated by glycyrrhizin pretreatment, i. e., 1-10mg esp. 1mg per 100g body weight per day intramuscularly for 5 days. Combined administration of glycyrrhizin with cortisone even weakened the stimulatory action of glycyrrhizin, although cortisone itself had a stimulatory action on cholesterogenesis.(2) Direct addition of glycyrrhizin in vitro to the incubation media containing liver slices of normal rats also increased cholesterogenesis at the concentration of 10-5-10-3M.(3) Excretion of intravenously injected cholesterol-4-14C into bile of bile duct-cannulated rats was much accelerated by glycyrrhizin pretreatment, 2mg per 100g body weight per day intramuscularly for 5 days. Rates of increase of radioactivities excreted into bile by glycyrrhizin pretreatment were 4.5 times, taurocholic acid; 2.8 times, taurochenodeoxycholic acid; 2.7 times, cholesterol; and 3.7 times, total 14C, respectively.(4) Fecal excretion of intraperitoneally injected cholesterol-4-14C was also stimulated by glycyrrhizin pretreatment. Total 14C and total bile acids-14C were increased up to about 2 times, while non-saponifiable materials-14C and 3β-OH-sterols-14C remained within 1.5 times.(5) Elimination of intravenously injected cholesterol-4-14C from plasma was accelerated by glycyrrhizin injection.(6) Glycyrrhizin treatment reduced plasma cholesterol and triglycerides levels of cholesterol diet fed rats.

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