Effect of electrochemical stimulation of the preoptic area on induction of ovulation in estrogenized rats(Note)

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  • ARAI YASUMASA
    Department of Anatomy, Juntendo University School of Medicine
  • MASUDA SAKAE
    Department of Anatomy, Juntendo University School of Medicine

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  • Effect of Electrochemical Stimulation of the Preoptic Area on Induction of Ovulation in Estrogenized Rats

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説明

The effect of neonatal treatment with estrogen on the development of the reguiatory centers of pituitary gonadotrophic function appears to be diffrent according to the dose of estrogen and the length of the injection period. Daily injections of 10μg estrone to female rats for the first 10 days of life resulted in the persistent vaginal estrus. The rats were sensitive to the electrochemical (EC) stimulation of the medial preoptic area (POA) and were capable of ovulating in response to the EC stimulation of the POA (6 out of 8 rats). In contrast, after prolonged treatment with large doses of estrone (the daily dose was increased with age, 50μg being injected during the first 10 days of life, 100 μg during then ext 10 days, and 200μg from days 21 to 30), the centers for pituitary gonadotrophin secretion were more severely affected. The rats showed the persistent vaginal diestrus and their preoptic-hypothalamic system was insenlsitive to the EC stimulation. Ovulationf ailed to occur following thes timulation in all of 8 rats.

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