Comparison of the IgG Subclass Distribution of Anti-thyroid Peroxidase Antibodies in Healthy Subjects with That in Patients with Chronic Thyrolditis.
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- KOHNO YOICHI
- Department of Pediatrics, School of Medicine, Chiba University
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- KIJIMA MASAMI
- Meiji Institute of Health Sciences
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- YAMAGUCHI FUMIHIRO
- Faculty of Pharmaceutical Sciences, Chiba University
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- SAITO KIMIYUKI
- Department of Pediatrics, School of Medicine, Chiba University
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- TSUNOO HAJIME
- Meiji Institute of Health Sciences
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- HOSOYA TOICHIRO
- Faculty of Pharmaceutical Sciences, Chiba University
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- NIIMI HIROO
- Department of Pediatrics, School of Medicine, Chiba University
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説明
The IgG subclass distribution of anti-thyroid peroxidase (TPO) antibodies in patients with chronic thyroiditis and in healthy subjects has been investigated. Anti-TPO antibodies in sera of patients with chronic thyroiditis were predominantly associated with IgG1, with a lesser contribution by IgG4 and IgG3. In contrast, anti-TPO antibodies of healthy subjects were exclusively associated with IgG4. Since structural differences in IgG subclasses reflect differences in their biological roles, these findings suggest that the role of anti-TPO antibodies in patients may differ from that in healthy subjects.
収録刊行物
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- Endocrine Journal
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Endocrine Journal 40 (3), 317-321, 1993
一般社団法人 日本内分泌学会