Growth hormone secretion in a patient with deprivation dwarfism(Note)

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  • IMURA HIROO
    Department of Medicine, Kyoto University School of Medicine, Kyoto, and Department of Medicine, Kitano Hospital
  • YOSHIMI TERUYA
    Department of Medicine, Kyoto University School of Medicine, Kyoto, and Department of Medicine, Kitano Hospital
  • KEKUBO KATSUJI
    Department of Medicine, Kyoto University School of Medicine, Kyoto, and Department of Medicine, Kitano Hospital

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  • Growth Hormone Secretion in a Patient with Deprivation Dwarfism

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Plasma levels of human growth hormone (HGH) were measured in a 16-year-old boy with deprivation dwarfism. Plasma HGH response to insulin-induced hypoglycemia was absent, whereas its response to arginine infusion was slightly subnormal.An exaggerated response of plasma HGH was observed when insulin was injected during the infusion of a beta adrenergic blocking agent, propranolol. Intravenous infusion of an alpha adrenergic stimulating agent, methoxamine, caused a significant increase in plasma HGH. Plasma HGH response to insulin-induced hypoglycemia was within normal limit when re-tested during the period of accelerated growth. These results suggest a functional disorder of HGH secretion in this patient, which seemed to be caused by the inhibition through beta adrenergic receptors.

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