- 【Updated on May 12, 2025】 Integration of CiNii Dissertations and CiNii Books into CiNii Research
- Trial version of CiNii Research Automatic Translation feature is available on CiNii Labs
- Suspension and deletion of data provided by Nikkei BP
- Regarding the recording of “Research Data” and “Evidence Data”
Association of serum adiponectin with asthma and pulmonary function in the Japanese population
-
- Hayashikawa Yasuko
- First Department of Internal Medicine, Faculty of Medicine, Toyama University, Toyama 930-0194, Japan
-
- Iwata Minoru
- First Department of Internal Medicine, Faculty of Medicine, Toyama University, Toyama 930-0194, Japan Community Medical Support Unit, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan
-
- Inomata Minehiko
- First Department of Internal Medicine, Faculty of Medicine, Toyama University, Toyama 930-0194, Japan
-
- Kawagishi Yukio
- Internal Medicine, Kurobe City Hospital, Kurobe 938-8502, Japan
-
- Tokui Kotaro
- First Department of Internal Medicine, Faculty of Medicine, Toyama University, Toyama 930-0194, Japan
-
- Taka Chihiro
- First Department of Internal Medicine, Faculty of Medicine, Toyama University, Toyama 930-0194, Japan
-
- Kambara Kenta
- First Department of Internal Medicine, Faculty of Medicine, Toyama University, Toyama 930-0194, Japan
-
- Okazawa Seisuke
- First Department of Internal Medicine, Faculty of Medicine, Toyama University, Toyama 930-0194, Japan
-
- Yamada Toru
- First Department of Internal Medicine, Faculty of Medicine, Toyama University, Toyama 930-0194, Japan Community Medical Support Unit, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan
-
- Hayashi Ryuji
- First Department of Internal Medicine, Faculty of Medicine, Toyama University, Toyama 930-0194, Japan
-
- Kamura Yutaka
- First Department of Internal Medicine, Faculty of Medicine, Toyama University, Toyama 930-0194, Japan
-
- Okazawa Teruyo
- First Department of Internal Medicine, Faculty of Medicine, Toyama University, Toyama 930-0194, Japan
-
- Matsui Shoko
- Health Administration Center, University of Toyama, Toyama 930-0194, Japan
-
- Kigawa Mika
- Department of Public Health, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan
-
- Tobe Kazuyuki
- First Department of Internal Medicine, Faculty of Medicine, Toyama University, Toyama 930-0194, Japan
Search this article
Description
Conflicting findings have been reported regarding the role of adiponectin in asthma. The aim of this study was to evaluate the association of adiponectin with pulmonary functions and asthma in the Japanese population. First, among a general population that participated in a previous study (group 1), we selected 329 subjects after excluding those with asthma, chronic obstructive pulmonary disease, and a smoking history and examined the associations of the serum total adiponectin levels with pulmonary functions. In a second cohort (group 2) consisting of 61 asthmatic patients and 175 control non-asthmatic subjects, we examined the associations between asthma and the levels of total, high (HMW), middle (MMW) and low (LMW) molecular weight adiponectin isoforms as well as the ratio of each isoform to total adiponectin level. Although the total adiponectin levels were not significantly different between the asthmatic and control subjects in group 2, the levels were significantly and positively associated with the forced expiratory volume in 1 s after adjustments for confounding factors (P < 0.05) in women in group 1. In group 2, the LMW adiponectin level was significantly higher and the MMW/total adiponectin ratio was significantly lower among the asthmatic subjects than among the control subjects after adjustments for confounding factors in both sexes (P < 0.05). The present study showed that a low total adiponectin level may lead to airway narrowing compatible with asthmatic airways in women, and higher LMW adiponectin levels and lower MMW/total adiponectin ratio are significantly associated with current asthma in both sexes.
Journal
-
- Endocrine Journal
-
Endocrine Journal 62 (8), 695-709, 2015
The Japan Endocrine Society
