進行性筋ジストロフィー症の染色体異常に関する研究

DOI
  • 中川 原寛一
    国立療養所西多賀病院研究検査科遣伝染色体検査室
  • 酒井 京子
    国立療養所西多賀病院研究検査科遣伝染色体検査室
  • 名取 徳彦
    国立療養所西多賀病院神経内科
  • 鴻巣 武
    国立療養所西多賀病院神経内科
  • 佐藤 元
    国立療養所西多賀病院神経内科
  • 遠藤 信
    国立療養所西多賀病院研究検査科血液,細菌検査室
  • 佐伯 三男
    国立療養所西多賀病院研究検査科血液,細菌検査室

書誌事項

タイトル別名
  • A Study of Chromosome Aberration in Progressive Muscular Dystrophy

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抄録

Lymphocytes cultures from Duchenne type of Progressive Muscular Dystrophy (DMD) (19 male, 1 female) and normal subjects (18 male, 2 female) were examind as to the frequency and location in X chromosome of the Spontaneous Sister Chromatid Exchanges (SCE) by the BrdU-AG method.<br>We have found considerable variation in the distribution of SCE at a site on the short arm of X chromosome (Xp21-22 or Xp22) in patients with DMD.<br>The analysis of G band in chromosome of DMD patient with the use of the Trypsin Giemsa method and a new staining method (BrdU-AG method) pioneered by our laboratory, revealed no significant chromosomal abnormality, but chromosome Gaps were found at a site on the autosomes.<br>It was suggested that the sites may have a error G2 replication system, and lympho-cytes from DMD may have a defective DNA repair system and a mistake of biochemical process.

収録刊行物

  • 医療

    医療 38 (3), 273-277, 1984

    一般社団法人 国立医療学会

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