Effect of Oral Hypoglycemic Agents on Occurrence of Ischemic Heart Disease

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  • 虚血性心疾患発症に及ぼす経口血糖降下剤の影響
  • キョケツセイ シンシッカン ハッショウ ニ オヨボス ケイコウ ケットウ コウカザイ ノ エイキョウ

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Abstract

ATP sensitivity potassium (KATP) channels exist in not only a pancreas β cell but also the cardiac muscle and the smooth muscle as well. The β cell, cardiac and smooth muscle types of KATP channels are involved in Insulin secretion, the cardiac muscle protection at myocardial ischemia and the vascular tone respectively. These sulfonylurea (SU) receptors exist as the subunits of the KATP channels and it is expected that the protection by the cardiac KATP channel and the tone regulation by the smooth muscle KATP channel decline at the closure by SU. Therefore SU receptor occupancy of the β cell, cardiac and smooth muscle was calculated by the pharmacokinetic parameters and the SU receptor affinity with the administration of the usual dose and compared variously with oral hypoglycemic agents to combine with SU receptors. The calculated SU receptor occupancy in the cardiac KATP channel by Glibenclamide and Glimepiride isn't very high. This result suggests that the effect of them on the cardiac muscle couldn't be denied completely.<br>Through investigating 110 diabetic cases to verify the effect of oral hypoglycemic agents occurrence of Ischemic Heart Disease (IHD), we found that the IHD group has more patients who have taken oral hypoglycemic agents compared to non-IHD group, however the difference was not very significant.

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