The Analysis of Liver Fibrosis in Patients with Hepatocellular Carcinoma Associated with Chronic Hepatitis C Virus Infection after Interferon-.ALPHA. Therapy.

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  • インターフェロン‐α（ＩＦＮ‐α）治療後肝細胞癌が発生した慢性Ｃ型肝炎ウイルス感染患者の肝線維化に関する研究
  • インターフェロン-a(IFN-a)チリョウ ゴ カン サイボウガン ガ ハッセイ シタ マンセイ Cガタカンエンウイルス カンセン カンジャ ノ カン センイカ ニ カンスル ケンキュウ

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We compared the serum marker and liver biopsy before the interferon-α therapy to those at the time of the occurence of hepatocellular carcinoma (HCC) in 15 patients with chronic hepatitis C virus infection (HCV) complicating with HCC after IFN-α therapy. Of 15 patients, 5 became sustained serum HCV RNA negative and 10 continued HCV RNA positive after IFN-α therapy. The follow-up period was 60.0 and 54, 3 months respectively. At the time of the occurence of HCC compared with that before IFN-α therapy, patients with sustained HCV RNA negative showed the decrease tendency of serum hyaluronic acid values and significant improvement of liver fibrosis in liver biopsy in contrast to in patients with HCV RNA positive indicating the increase tendency of serum hyaluronic acid values and progression of liver fibrosis in liver biopsy. Because all the stage of liver fibrosis except 1 patient was F 3-4 before IFN-α therapy irrespective of the response to IFN-α therapy, we concluded that patients with chronic HCV infection with stage F 3-4 of liver

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