パーキンソン病の１亜型としての純粋型びまん性レビー小体病

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  • Pure Diffuse Lewy Body Disease as a Subtype of Parkinson Disease.
  • パーキンソンビョウ ノ 1 アケイ ト シテ ノ ジュンスイガタビマンセイ レビー コテイビョウ

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説明

Parkinson disease (PD) is a neurodegenerative diesese, characterized by various neurological symptoms including resting tremor, bradykinesia, rigidity, and pulsion. It is estimated that there are as many as 120, 000 patients with PD in Japan. Lewy bodies (LBs), intracytoplasmic neuronal inclusion bodies, are identified in subcortical nuclei, including substantia nigra, of Parkinson disease. “Diffuse Lewy body disease (DLBD)” is an entity in which LBs are diffusely distributed in various neural tissues, including neocortex, resulting in that the patients demonstrate several symptoms, like dementia, as well as parkinsonism. There seem to be more than 200, 000 patients with DLBD in Japan. Among patients with DLBD, “pure form”, which lacks Alzheimer's pathologic changes, appears to have about 20, 000 patients. “Pure form” of DLBD shares common clinical and pathologic features with PD, therefore, this entity could be considered as a subtype of PD. As PD is believed to occur due to multiple pathogenic factors, an additional factor may cause “pure form” of DLBD in some patients with PD.

収録刊行物

  • 医療

    医療 55 (12), 587-591, 2001

    一般社団法人 国立医療学会

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