Prion's Disease. A Case of Creutzfeldt-Jakob Disease Manifested the Clinical Symptoms Just After an Operation of a Chronic Subdural Hematoma: the Usefulness of Diffusion Weighted MR Imaging to the Early Diagnosis.

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  • YUASA Tatsuhiko
    National Center of Neurology and Psychiatry
  • NEMOTO Hideaki
    Department of Neurology, Kohnodai Hospital, National Center of Neurology and Psychiatry
  • KIMURA Akio
    Department of Neurology, Kohnodai Hospital, National Center of Neurology and Psychiatry
  • YOSHINO Hiide
    Department of Neurology, Kohnodai Hospital, National Center of Neurology and Psychiatry
  • YAMADA Shigeo
    Department of Neurology, Kohnodai Hospital, National Center of Neurology and Psychiatry
  • NISHIMIYA Jin
    Department of Neurology, Kohnodai Hospital, National Center of Neurology and Psychiatry

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Other Title
  • プリオン病　　慢性硬膜下血腫除去術直後に発症し，拡散強調ＭＲ調画像が早期診断に有用であったＣｒｅｕｔｚｆｅｌｄｔ‐Ｊａｋｏｂ病の１例
  • マンセイコウマク カケッシュ ジョキョジュツ チョクゴ ニ ハッショウ シ,カクサン キョウチョウ MRチョウガゾウ ガ ソウキ シンダン ニ ユウヨウ デ アッタ Creutzfeldt-Jakobビョウ ノ 1レイ

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This is an unusual case of CJD manifested its symptoms just after an operation of a chronic subdural hematoma. Before the operation it would be impossible to suspect the exsistence of CJD, and even after the operation it was also difficult to diagnose the disease. However, a close clinical observation and the diffusion weighted MRI of the brain enabled the prompt diagnosis of CJD, and at that time EEG did not yet show any periodic synchronous discharges. The initial symptoms of the patient showed a marked laterality and the brain lesions appeared in MRI were diffusely scattered but dominantly on the left (hematoma) side of the brain. This case also suggests the importance of the preparation of guidelines for surgical treatments to the CJD patients or persons at risk based on a well designed and integrated infection control protocol.

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