Significance of anti-SSA/Ro52 and anti-SSA/Ro60 antibodies in a mother experiencing complications related to collagen disease A family study of a mother and her two children

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  • 膠原病合併母体における抗ＳＳＡ／Ｒｏ５２抗体および抗ＳＳＡ／Ｒｏ６０抗体の意義　　一家系の母と子での検討
  • コウゲンビョウ ガッペイ ボタイ ニ オケル コウSSA Ro52 コウタイ オヨビ コウSSA Ro60 コウタイ ソクテイ ノ イギ イチ カケイ ノ ハハ ト コ デ ノ ケントウ

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When anti-SSA/Ro or anti-SSB/La antibodies are produced in a perinatal mother, they are transported to the fetus via the placenta, causing congenital heart block. The SSA/Ro antigen is divided into 52kd protein and 60kd protein types, and if the child tests positive for the anti-SSA/Ro52kd antibody, it has a high risk of developing heart block. Therefore it is of critical importance to distinguish between the anti-52kd antibody and the anti-60kd antibody in order to predict the birth of an affected child and to provide pre-and post-natal treatment.<br>Previously, we reported a case of a child with infantile lupoid hepatitis born to a mother with autoimmune hepatitis. Subsequently, the mother gave birth to a healthy boy under hospital care during her second pregnancy. We paid attention to this child and, with the consent of his family, measured the anti-SSA/Ro52 and anti-SSA/Ro60 antibody in his mother risk factors after birth.<br>The results were negative for anti-SSA/Ro60 antibody and positive for anti-SSA/Ro52 antibody (124.26), revealing that the child had been at high risk of developing congenital heart block. Careful ultrasound imaging performed at 18, 20, 21, 22, 23, and 24 weeks of fetal development and control via steroid therapy appear to have contributed to the birth of a healthy child.

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