CURRENT STATUS AND THE FUTURE OF KERATOPLASTY

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  • YAMADA Masakazu
    Division for Vision Research, National Tokyo Medical Center, National Institute of Sensory Organ
  • MOCHIZUKI Hiroshi
    Division for Vision Research, National Tokyo Medical Center, National Institute of Sensory Organ

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  • 感覚器（五感の科学）　　角膜移植の現状と将来
  • カクマク イショク ノ ゲンジョウ ト ショウライ

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Abstract

Over the past 70 years, keratoplasty has become the most established method of organ transplantation, with approximately 2, 600 donor corneas used for transplantation annually in Japan. Graft survival rates of penetrating keratoplasty, the most frequent technique of keratoplasty, are over 90% at 1-year, and 80-90% at 5-years. The major complications of penetrating keratoplasty include allograft rejection, secondary glaucoma, and infection. To reduce the risk of complications, novel techniques such as limbal transplantation, deep lamellar keratoplasty, deep lamellar endothelial keratoplasty, development of cornea equivalent, and keratoprosthesis, have been investigated, and some of these are in clinical use. In Japan, patients requiring keratoplasty have to wait for donor corneas for 2 years on average. More effort should be given to public relations and education for the eye bank.

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