肺がん症例における免疫機能不全　　特に血清中の免疫抑制因子とその作用について

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書誌事項

タイトル別名
  • IMPAIRED IMMUNITY IN LUNG CANCER PATIENTS
  • ハイガン ショウレイ ニ オケル メンエキ キノウ フゼン トクニ ケッセイチ
  • ―特に血清中の免疫抑制因子とその作用について―

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説明

There are numerous reports showing the depressed immune functions in lung cancer patients using in vivo and in vitro testings. We, in this paper, described the physical and biologic properties of a naturally occurring immunosuppressive factors in serum of human both normal person and patients with a wide variety of diseases, and that those factors played an immunoinhibitory or immunoregulatory role in immune responses. However, the precise role, properties and active substances of those factors still remain to be fully determined.<br>We also described a possible correlation between depressed immune function in lung cancer and immunosuppressive factors occurring in serum of lung cancer patients. The immunosuppression in lung cancer may be partly due to those factors.<br>The biological characteristic of immunosuppressive factors in serum of lung cancer in our laboratories previously reported is long acting in mode of action in immunosuppression.<br>An attempt was made to try Serum Immunosuppression test using the nature of those factors. In vivo transfer experiment of immunosuppressive activity indicated that immunosuppression in this test was due to suppressor cell induced through serum factor and cell interaction in animal.<br>The further isolation and purification of these factors will be most important in future.<br>We believe it may be expected that these factors become useful for not only as an immunoregulatory factor but also cancer immunotherapy, immunodiagnosis of cancer and an immunosuppressive agents.

収録刊行物

  • 医療

    医療 36 (4), 305-314, 1982

    一般社団法人 国立医療学会

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