Spinal fluid NSE, LDH and CPK, and serum CPK and CPK-BB in neonatal central nervous system diseases.

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  • 中枢神経障害新生児におけるＮＳＥ，ＬＤＨ，ＣＰＫ値について

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Abstract

For diagnosis, severity and prognosis of neonatal central nervous system (CNS) diseases, we made a study of spinal fluid NSE, LDH and CPK, and serum CPK and CPK-BB in neonates. Examination of overall CNS diseases including intracranial hemorrhage, asphyxia neonatorum, convulsion, meningitis, etc, demonstrated that the values of the markers in the disease groups were significantly higher than those in the normal group. In terms of individual diseases, the intracraneal hemorrhage group showed significantly high values for spinal fluid NSE and LDH and serum CPK, likewise the asphyxia neonatorum group for spinal fluid LDH, and the convulsion group for spinal fluid LDH and serum CPK, in comparison with the normal group. In relation to prognosis, the cerebral palsy group had significantly high spinal fluid NSE and LDH values. In the mental retardation group, the marker values were higher but showed no significant differences from those in the normal group. From all these findings, spinal fluid NSE and LDH were considered to be very effective markers in the diagnosis of and the determination of prognosis of neonatal CNS diseases.

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