乳癌による高カルシウム血症

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書誌事項

タイトル別名
  • Hypercalcemia in Carcinoma of the Breast
  • ニュウガン ニ ヨル コウカルシウム ケツショウ ソノ リンショウテキ コウサツ ト Thyrocalcitonin ニ ヨル チリョウ チケン ニ ツイテ
  • Clinical Considerations and the Experience of Thyrocalcitonin
  • ―その臨床的考察とThyrocalcitoninによる治療知見について―

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説明

Clinical symptoms in hypercalcemia by carcinoma of the breastare apt to escape from attention, because they resemble general symptoms of patients with carcinoma in the terminal stage. Even if the diagnosis is appropriately made, the prognosis is poor, resulting in death with 3 to 6 months from the first hypercalcemic crisis. This paper reports the clinical aspects and the therapeutic experience of hypercalcemia by thyrocalcitonin.<br>The initial symptomatology of hypercalcemia includes thirst and polyuria in renal function;nausea, vomiting and anorexia in gastrointestinal tract; and apathy, headache, convulsion and coma in nervous system.<br>Objectively, tachycardia, shortening of Q-aTc time in electrocardiogram and elevation of serum calcium and alkaline phosphatase are noted. When bone metastasis of breast carcinoma is diagnosed or suspected, it is important to check whether hypercalcemia is present or not and not to regard these symptoms as general complaints observed in patients with advanced carcinoma. In carcinoma of the breast, one of the causes of hypercalcemia is osteolytic bone metastasis, but the others are parathyroid hormone-like substances derived from tumors and osteolytic sterol, we think.<br>And also the fact must be taken that hypercalcemia is derived from sex hormones which are utilized to bone metastasis of breast carcinoma. As the treatment of hypercalcemia, massive transfusion and steroids have been used in order to decrease blood calcium level and to excrete calcium from urinary tract. Nevertheless, these treatments were temporary, and the patients died of renal and respiratory insufficiencies due to calcification of kidney and lung. To apply thyro-calcitonin, which make the level of blood calcium lower, to the patients with hypercalcemia, we tried to use porcine lyophilized calcitonin (Armour Pharmaceutical Co. ) to two patients with bone metastasis by breast carcinoma. As a result, one is prominent in effect and another is temporary, and serum calcium of both cases was controlled during relatively long term. These cases are now under followup

収録刊行物

  • 医療

    医療 28 (2), 127-132, 1974

    一般社団法人 国立医療学会

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