Studies on the Radioisotope Renogram in Senile Hypertension

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  • 老年者高血圧症のレノグラムによる研究
  • ロウネンシャ コウケツアツショウ ノ レノグラム ニ ヨル ケンキュウ

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Abstract

Purpose and Method: Senile hypertension is characteristic of systolic high blood pressure and good prognosis on the basis of sclerosis of elastic arteries especially thoracic and arcus aorta. In such view points it must be strictly distinguished from essential hypertension. In order to find the relationship between the renogram and laboratory data of senile hypertension, physical examination, funduscopic examination, laboratory studies of urine, serum electrolyte and total cholesterol, chest X-ray, EKG, PSP excretion test and renograms were carried out on 40 cases of out-patients over 60 years old, who had systolic level of higher than 150mmHg B. P., and no past history concerning hypertension.<br>On analysing the renograms, total concentration (TC), minute concentration (MC), minute excretion (ME) were calculated by Krueger's method, and time from maximum counting ratio to half value on c-segment (T1/2), angle of b-segment (θ) were measured.<br>Results: The renogram appeared following outcomes in senile hypertension; TC: 64.5±12.2%, MC: 26.8±6.9%, ME: 14.1±6.1%, T1/2: 7′47″±2′54″, θ: 57.2º±9.5º. All these values were somewhat inferior to those of the normotensive group of same age, but presented prominent decrease of ME and prolongation of T1/2 compared with those of juvenile hypertensive and healthy group from 15 to 35 years old. Spread of the data was also remarkable in senile hypertension. PSP excretion rate correlated positively to MC, ME and θ (coefficients of correlation: +0.477∼+0.678), inversely to T 1/2 (coefficients of correlation -0.561∼-0.598). Systolic blood pressure revealed negative correlation to MC and ME but diastolic pressure did nothing peculiar. The higher grade of Keith Wagener, the lower MC, ME and cases having EKG abnormalities also indicated decrease of ME. Serum cholesterol cardio-thoracic ratio, nycturia, urinalysis did not correlate to MC and ME.<br>Conclusions: In senile hypertension renogram data showed inclination of negative correlation to systolic blood pressure but no significant difference to those of senile normotensives. Fairly good correlationships were recognized between MC, ME and PSP excretion rate.

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