Electroencephalographic Studies on the Optimum Depth of Trichlorethylene Anesthesia

KOMEICHI Yoshinori

doi:10.11261/iryo1946.13.678

On six women and eight dogs, EEG, ECG and respiratory curve were simultaneously recorded during trichiorethylene anesthesia. At the same time, the concentration of trichlorethylene in blood was measured. The obtained results are as the following:<br>1) On the human subjects, during the anesthesia, the EEG were supressed in the begining and then the amplitude increased and the basic cycle declined to slow in proportion to the increase of the concentration of trichlorethylene in blood: i. e. from 10∼8c/s, into 8∼6c/s, 6∼4c/s and 4∼2c/s.<br>The frequencies of the heart beat and the respiration increased until the basic cycle of EEG indicated 8∼6c/s. Afterwards the frequencies were sustained “unchanged” in spite of the deeper anesthesia. In the process of the anesthesia no noticeable findings were observed.<br>2) On the experiments among dogs, one out of the eight dogs died during inhalation of trichlorethylene over one hour. Paralleling the anesthesia, the cycle of EEG became slow and heart beat and respiration became frequent. The concentration of trichlorethylene in blood increased over 20mg/dl at the final stage. In the fatal case it was measured over 30mg/cl.<br>3) The optimum depth of trichlorethylene anesthesia was when the frequency of EEH indicated 8∼6c/s, and the concentration of trichlorethylene in blood at the time showed 5.5 to 8.5mg/dl.

Electroencephalographic Studies on the Optimum Depth of Trichlorethylene Anesthesia

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