Studies on the Tuberculin Reactivity of Tuberculin-Active Peptide<sup>1</sup>

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  • SOMEYA Shiro
    Department of Microbiology, Institute of Public Health Department of Tuberculosis, National Institute of Health Department of Internal Medicine, University of Osaka School of Medicine
  • KOYAMA Kenjiro
    Department of Microbiology, Institute of Public Health Department of Tuberculosis, National Institute of Health Department of Internal Medicine, University of Osaka School of Medicine
  • ASAMI Nozomu
    Department of Microbiology, Institute of Public Health Department of Tuberculosis, National Institute of Health Department of Internal Medicine, University of Osaka School of Medicine
  • KATAOKA Tetsuo
    Department of Microbiology, Institute of Public Health Department of Tuberculosis, National Institute of Health Department of Internal Medicine, University of Osaka School of Medicine
  • YAMAMURA Yuichi
    Department of Microbiology, Institute of Public Health Department of Tuberculosis, National Institute of Health Department of Internal Medicine, University of Osaka School of Medicine

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  • Studies on the tuberculin reactivity of tuberculin-active peptide
  • Studies on the Tuberculin Reactivity of Tuberculin‐Active Peptide

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Abstract

A comparative study of the tuberculin potency and reactivity to TAP and PPD-S was made in humans and guinea pigs. A comparison of reactions elicited by TAP and PPD-S was made in two groups of guinea pigs previously inoculated with killed bacilli or with living bacilli. The tuberculin reactions produced by TAP and PPD-S in human beings was studied in school children from rural districts. These children were divided randomly into three groups and each group was given a different amount of TAP and PPD-S. The results obtained are as follows: (1) While relative potency of TAP was relatively much weaker than PPD-S in guinea pigs sensitized with tubercle bacilli, in human beings the tuberculin potency of TAP was approximately 1/2 or 1/3 that of PPD-S. (2) There was a marked difference in the tuberculin reactivity to TAP and PPD-S between guinea pigs immunized with killed bacilli and guinea pigs immunized with living bacilli.

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