Enhanced Synthesis of Phosphatidylethanolamine in Chick Embryo Cells Infected with Sendai Virus of Parainfluenza Type 1

SHIBUTA Hiroshi, MATUMOTO Minoru

doi:10.1111/j.1348-0421.1972.tb00647.x

Enhanced Synthesis of Phosphatidylethanolamine in Chick Embryo Cells Infected with Sendai Virus of Parainfluenza Type 1

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SHIBUTA Hiroshi

Department of Viral Infection, Institute of Medical Science, University of Tokyo, P. O. Takanawa
MATUMOTO Minoru

Department of Viral Infection, Institute of Medical Science, University of Tokyo, P. O. Takanawa

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説明

³H-Serine principally labeled phosphatidylserine (PS) and phosphatidylethanolamine (PE) of lipids of chick embryo cells. ³H-Ethanolamine labeled almost entirely PE of lipids of the cells. In turnover experiment with ³H-serine incorporated into cells before infection, the pathway from PS to PE was shown to become more active by Sendai virus infection. Similar turnover experiment using ³H-ethanolamine revealed that PE synthesis directly utilizing ethanolamine was also slightly enhanced by the infection. The most marked difference of infected cells from control cells was the enhanced rate of ³H-serine incorporation into lipids- These results indicated that the Sendai virus infection enhanced the metabolic pathway serine-PS-PE.