Delayed type hypersensitivity in hamsters infected with Mycoplasma pneumoniae as revealed by macrophage migration inhibition test

ARAI Sumio, HINUMA Yorio, MATSUMOTO Keizo, NAKAMURA Takashi

doi:10.1111/j.1348-0421.1971.tb00612.x

Delayed type hypersensitivity in hamsters infected with Mycoplasma pneumoniae as revealed by macrophage migration inhibition test

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ARAI Sumio

Department of the First Internal Medicine, School of Medicine
HINUMA Yorio

Department of the First Internal Medicine, School of Medicine Department of Microbiology, School of Dentistry, Tohoku University
MATSUMOTO Keizo

Department of the First Internal Medicine, School of Medicine
NAKAMURA Takashi

Department of the First Internal Medicine, School of Medicine

書誌事項

タイトル別名

Delayed Type Hypersensitivity in Hamsters Infected with <i>Mycoplasma pneumoniae</i> as Revealed by Macrophage Migration Inhibition Test

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説明

A delayed type hypersensitivity was demonstrated in hamsters infected with a fresh isolate of Mycoplasma pneumoniae by the following two procedures of macrophage migration inhibition test. In the first procedure, inhibition of migration of peritoneal exudate cells from normal guinea pigs by the addition of splenic cells from infected hamsters in the presence of the mycoplasma antigen was examined. In the second procedure, migration of peritoneal exudate cells, composed of macrophages and lymphocytes, from infected hamsters was examined after the addition of the antigen. Virtually, both procedures gave a similar result, suggesting the presence of cell-mediated immunity in the infected animals. In these infected hamsters, humoral antibody responses were also demonstrated at the same time.