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- HASHIMOTO Hajime
- Department of Microbiology, School of Medicine, Gunma University
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- IYOBE Shizuko
- Department of Microbiology, School of Medicine, Gunma University
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- MITSUHASHI Susumu
- Department of Microbiology, School of Medicine, Gunma University
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説明
Thirty mutants sensitive to tetracycline were obtained from an R100 factor capable of conferring resistance to tetracycline (TC), chloramphenicol (CM), streptomycin (SM) and sulfanilamide (SA). Among the TC sensitive mutants, three showed a high frequency of spontaneous loss from host strains. The genetic loci governing the stability of R factor in host bacteria were denoted as stb. The stb- R factors have lost many of the properties of a wild type R factor, such as, the capability to sexually transfer drug resistance and host chromosome, to confer superinfection immunity and to inhibit F function. All of these properties did not revert to a wild type phenotype, suggesting that these mutations are deletions including genetic determinants governing both TC resistance and stability of R factor. Recombinational analysis between stb- and stb+ R factors indicated that crossovers between the stb loci and those governing CM (or SM.SA) resistance took place at high frequency. No crossovers were detected between stb loci and those governing TC resistance, indicating that the stb loci are linked closely to the loci governing TC resistance.
収録刊行物
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- Japanese Journal of Microbiology
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Japanese Journal of Microbiology 13 (4), 343-349, 1969
財団法人 学会誌刊行センター
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詳細情報 詳細情報について
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- CRID
- 1390001206319902720
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- NII論文ID
- 130004237087
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- NII書誌ID
- AA00246855
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- COI
- 1:CAS:528:DyaE3cXpslGqug%3D%3D
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- NDL書誌ID
- 8511665
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- ISSN
- 00215139
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- PubMed
- 4902131
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可