Opsonization of <i>Staphylococcus aureus</i> by Guinea Pig 7S Gamma-Globulin

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  • Downey Ronald J
    Department of Microbiology, University of Notre Dane, Notre Dame Department of Zoology and Microbiology, Ohio University

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  • Opsonization Staphylococcus aureus by guinea pig 7S gamma-globulin
  • Opsonization of <i>Staphylococcus aureus</i> by Guinea Pig 7S Gamma‐Globulin

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Opsonization of Staphylococcus aureus to phagocytosis by guinea pig peritoneal exudate cells (PEC) was examined with various isolated serum globulins. Significant enhancement of in vitro phagocytosis was afforded by partially purified 7Sγ1-immunoglobulin. The rate of killing or the rate of ingestion of 3H-thymidine labeled bacteria by PEC was used as an index of phagocytosis. The results indicate that the immunoglobulin can mediate the adsorption of an allogeneic surface independent of a specific antigenic component.

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