Dose Effect of Immune Ribonucleic Acid Fraction on Antibody Formation

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  • KITAMURA Kouichi
    Department of Microbiology, School of Medicine, Gunma University Central Research Laboratories, Sankyo Co., Ltd.
  • KURASHIGE Satonori
    Department of Microbiology, School of Medicine, Gunma University
  • MITSUHASHI Susumu
    Department of Microbiology, School of Medicine, Gunma University

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An immune ribonucleic acid (RNA) preparation was extracted with phenol from the spleens of mice immunized with sheep red blood cells (SRBC). When mice were injected intravenously with iRNA, rosette formers in the spleens of such mice were demonstrated but plaque formers and serum antibody could not be detected. As reported previously, iRNA against SRBC also could induce memory cells capable of responding to a small amount of antigen to produce a high titer of antibody. The necessary interval between the iRNA and antigen stimulation for induction of a secondary response was found to be three weeks or more. Presence of an optimal dose of iRNA for the induction of memory cells was demonstrated, and the role of iRNA in antibody formation and the optimal dose of iRNA for the induction of memory cells were discussed.

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