Suppressive Effect of Curcumin on Trichloroethylene-induced Oxidative Stress.
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- WATANABE Satoshi
- Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
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- FUKUI Tetsuya
- Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
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In vivo antioxidative effects of curcumin were investigated using a trichloroethylene (TCE)-induced oxidative stress model in mouse liver. Increases in the con-tents of peroxisome and thiobarbituric acid reactive substances (TBARS) and decreases in GSH content of mouse liver by the TCE administration were suppressed by the pre-adminis-tration of curcumin. TCE-induced changes in the activities of antioxidative enzyme, such as Cu/Zn-SOD, catalase, glutathione reductase, glutathione peroxidase (GPx) and D-glucose-6-phosphate dehydrogenase (G6PD), were also diminished by curcumin. These results indi-cate that curcumin significantly suppresses TCE-induced oxidative stress by scavenging var-ious free radicals, and its antioxidative activity seems to be derived from its suppressive ef-fects on the increase in peroxisome content and decrease in GPx and G 6PD activities.
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｎｕｔｒｉｔｉｏｎａｌ Ｓｃｉｅｎｃｅ ａｎｄ Ｖｉｔａｍｉｎｏｌｏｇｙ
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Ｊｏｕｒｎａｌ ｏｆ Ｎｕｔｒｉｔｉｏｎａｌ Ｓｃｉｅｎｃｅ ａｎｄ Ｖｉｔａｍｉｎｏｌｏｇｙ 46 (5), 230-234, 2000
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詳細情報 詳細情報について
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- CRID
- 1390001206320835584
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- NII論文ID
- 10010804502
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- NII書誌ID
- AA00703822
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 5585093
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- PubMed
- 11234915
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可