Mucosal lymphatic vessels of the esophagus distant from the cancer margin: morphometrical analysis using 27 surgically removed specimens of squamous cell carcinoma located in the upper or middle thoracic esophagus
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- NISHIMORI Hidefumi
- Division of Surgery, Keiyu-kai Sapporo Hospital
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- HAYASHI Shogo
- Medical Education Center, Aichi Medical University
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- NAITO Munekazu
- Department of Anatomy, Tokyo Medical University
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- MURAKAMI Gen
- Iwamizawa Kojin-kai Hospital
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- FUJITA Masahiro
- Keiyu-kai Institute of Clinical and Surgical Pathology
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- HOSOKAWA Masao
- Division of Surgery, Keiyu-kai Sapporo Hospital
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説明
Purpose: to clarify the configuration of the esophageal mucosal lymphatics distant from cancer using D2-40 immunohistochemistry.<br>Methods: D2-40 immunohistochemistry for human lymphatic epithelium was performed at sites about 10 cm anal from the pathologically examined margin of upper or mid-thoracic squamous cell carcinoma (27 patients). we measured the entire length of mucosal lymphatic vessels within a ×10 objective field (1.2 mm along the muscularis mucosae).<br>results: the present morphometrical study demonstrated significant individual differences in the amount of mucosal lymphatic vessels, within a range of more than 10-fold (8.4 mm-0.8 mm within an objective field). However, the difference in length of the mucosal lymphatic epithelium did not correlate with either N-factor, t-factor including cancer depth or prognosis.<br>Conclusion: a higher density of pre-existing mucosal lymphatic vessels may not always be correlated with larger numbers of nodal metastases. Lymphatic proliferation or dilation induced by cancer seems to occur irrespective of whether pre-existing vessels are rich or sparse.
収録刊行物
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- Ｏｋａｊｉｍａｓ Ｆｏｌｉａ Ａｎａｔｏｍｉｃａ Ｊａｐｏｎｉｃａ
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Ｏｋａｊｉｍａｓ Ｆｏｌｉａ Ａｎａｔｏｍｉｃａ Ｊａｐｏｎｉｃａ 88 (2), 43-47, 2011
オカジマ・フォリア・アナトミカ・ヤポニカ編集部
