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GLUTAMIC DECARBOXYLASE AND γ-AMINOBUTYRIC-α-KETOGLUTARIC TRANSAMINASE ACTIVITIES DURING AND ON SUPRESSION OF THE RUNNING FIT
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- NISHIZAWA YOSHITO
- Department of Pediatrics, Faculty of Medicine, Osaka University
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- KODAMA TEISUKE
- Department of Pediatrics, Faculty of Medicine, Osaka University
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- KOBAYASHI SHIGEO
- Department of Pediatrics, Faculty of Medicine, Osaka University
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Description
1. Brain glutamic decarboxylase is inhibited in the OMP-induced running fit, but γ-aminobutyric-α-ketoglutaric transaminase is not inhibited.<br>2. Both enzymes show normal activities when the seizure is prevented by pyridoxine.<br>3. MAAMP inhibits γ-aminobutyric-α-ketoglutaric transaminase to a greater extent than glutamic decaboxylase.<br>4. In preventing the OMP running fit with MAAMP, it is more effective to give it before OMP.<br>5. The inhibition of glutamic decarboxylase by OMP is slighter when the running fit is prevented by MAAMP.<br>6. Both glutamic decarboxylase and γ-aminnobutyric-α-ketoglutaric transaminase are inhibited in the thiosemicarbazide-induced running fit, but when the seizure is prevented by pyridoxine, there is no inhibition.<br>7. From these results, it is assumed that brain aminobutyric acid is decreased when the running fit occurs but is not reduced when the running fit is prevented by pyridoxine.
Journal
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- THE JOURNAL OF VITAMINOLOGY
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THE JOURNAL OF VITAMINOLOGY 5 (4), 241-248, 1959
THE VITAMIN SOCIETY OF JAPAN
