Antigenic Analysis of Acute Hemorrhagic Conjunctivitis Viruses (Enterovirus Type 70)

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  • Antigenic Analysis of Acute Hemorrhagic

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Abstract

The antigenic characteristics of enterovirus type 70 (EV 70) were investigated by means of cross and kinetic neutralization tests (NT). Twelve strains of EV 70 isolated in a period from 1971 to 1976 were analyzed using seven rabbit and one monkey hyper-immune sera. All the strains investigated were found to possess a common and prime variant antigens in varying proportions.<BR>Accordingly, EV 70 isolates were divided intratypically into three antigenic subgroups; (1) prototype-like (four strain from 1971 to 1972), (2) intermediate, G-10/72-like (two strains from 1972 to 1973), and (3) prime variant, G-2/74-like (six strains from 1974 to 1976) groups.<BR>Thus it was considered that EV 70 might represent a virus type with antigenic heterogeneity, and that antigenic drift from the prototype to the prime type may have occurred successively after 1971.

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