モルモット体内における鼠癩菌の態度

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書誌事項

タイトル別名
  • The Behavior of Murine Leprosy Bacilli in Guinea-pigs
  • モルモットの皮下に接種された鼠癩菌について
  • モルモット ノ ヒカ ニ セッシュ サレタ ネズミライキン ニ ツイテ
  • (第2報)モルモットの皮下に接種された鼠癩菌について
  • (Part 2) The Growth Pattern of Murine Leprosy Bacilli Subcutaneously Inoculated in Guinea-pigs

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It is essential to study on the relation between macrophage and parasite in murine leprosy. However, in the previous experiments (Part 1) no finding could be obtained, concerning the macrophage-parasite relationship, although multiplication and viability of the bacilli were estimated by counting of the bacilli and reverse transfer. Therefore we have conducted the following experiment with regard to the macrophage-parasite relationship.<br>Guinea-pigs were subcutaneously inoculated in the back with suspension of murine leprosy bacilli. With intervals of 5 days, the subcutaneous conective tissues at the inoculation site were removed and spread on a glass slide and the behavior of the bacilli within mononuclears was examined. After 5 days, elongation of the bacilli was observed in mononuclears, and 15 days later many enlarged mononuclears filled with the elongated bacilli appeared at the site of inoculation. From the findings of this observation and of reverse transfer, it seemed that the growth patterns of murine leprosy bacilli subcutaneously inoculated into the guinea-pigs were identical with those in mice until 15 days after inoculation. But from then on infectivity of the bacilli in the guinea-pigs became remarkably reduced with time. After 30 days, non-leprous granuloma appeared at the inoculation site and the number of bacteria was significantly decreased.<br>Similar experiment; inoculation from Kirchner's medium back to the mouse, was performed to examine the viability of the in vitro cultured organisms. Elongation of the bacilli occurred in Kirchner's medium, but viability of the in vitro cultured bacilli was excessively reduced with time.<br>Based on these observations we have considered that macrophages of guinea-pigs play a role in multiplication of murine leprosy bacilli only in a short duration (about 15 days). It is desirable to prolong that short duration for evelopment of the study on transmission of murine leprosy to guinea-pigs, although no significant result was obtained in our attempts under present conditions.

収録刊行物

  • レプラ

    レプラ 38 (1), 5-9, 1969

    日本ハンセン病学会

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